TRIM7

Across TCGA patient cohorts, TRIM7 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM7-associated genes across cancer lineages are Rad50, Annexin-1, and 14-3-3_beta. Each is linked with TRIM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM7-to-partner and partner-to-TRIM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by TRIM7-low versus TRIM7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM7→partner) and Y-score (partner→TRIM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.241	-1.502	.006	.030	3	2
UCEC	Annexin-1 →	+0.465	+1.502	.016	.030	3	2
UCEC	14-3-3_beta →	-0.099	-3.295	.007	.009	3	1
UCEC	A-Raf_pS299 →	-0.113	-2.000	.010	.030	3	1
UCEC	ERK2 →	+0.178	+3.459	.012	.005	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.381	+1.594	.041	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Rad50 by TRIM7 expression — UCEC

Explore this box plot interactively →