TRIM7

Across TCGA cell cohorts, TRIM7 mutation is significantly associated with the mutation status of many other genes, with 1,711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM7-associated genes across cancer lineages are ITGA2B, KLHL1, and TSHZ1. Each is linked with TRIM7 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM7-to-partner and partner-to-TRIM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGA2B grouped by TRIM7-low versus TRIM7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM7→partner) and Y-score (partner→TRIM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ITGA2B →	+5.066	+4.502	.007	.007	1	4
CNS	KLHL1 →	+5.614	+5.044	.003	.003	1	3
LUNG_NSCLC_LUAD	TSHZ1 →	+4.339	+4.339	.009	.009	1	3
LARGE_INTESTINE	USP16 →	+3.350	+4.584	.003	.003	1	3
LARGE_INTESTINE	CTBP1 →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	TMEM161B →	+3.672	+4.799	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,711 associations by consensus.

ITGA2B by TRIM7 expression — LUNG_SCLC

Explore this box plot interactively →