TRIM66

Across TCGA patient cohorts, TRIM66 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM66-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and ASNS. Each is linked with TRIM66 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM66-to-partner and partner-to-TRIM66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TRIM66-low versus TRIM66-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM66→partner) and Y-score (partner→TRIM66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.247	-2.087	.002	.005	3	2
UCEC	PDCD4 →	-0.452	-2.492	.003	.001	3	2
COAD	ASNS →	+0.536	+2.330	.002	.020	3	2
COAD	ATM →	-0.662	-2.313	<.001	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.620	+1.716	.001	.003	3	2
UCEC	14-3-3_beta →	-0.129	-1.986	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

EGFR_pY1068 by TRIM66 expression — UCEC

Explore this box plot interactively →