TRIM66

Across TCGA cell cohorts, TRIM66 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,388 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TRIM66-associated GO terms across cancer lineages are Microtubule nucleation, R-loop processing, and Negative regulation of DNA-templated transcription initiation. Each is linked with TRIM66 in more than 15 cancer types. Because this analysis shows association rather than direction, both TRIM66-to-partner and partner-to-TRIM66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by TRIM66-low versus TRIM66-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM66→partner) and Y-score (partner→TRIM66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule nucleation →	+0.117	+0.967	.001	<.001	3	16
LARGE_INTESTINE	R-loop processing →	+0.119	+1.369	<.001	<.001	3	15
LARGE_INTESTINE	Negative regulation of DNA-templated transcription initiation →	+0.110	+0.861	.001	.004	3	15
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.110	+0.861	.001	.004	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.098	-0.789	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.137	-1.310	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,388 associations by consensus.

Microtubule nucleation by TRIM66 expression — BONE

Explore this box plot interactively →