TRIM66

Across TCGA cell cohorts, TRIM66 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM66-associated genes across cancer lineages are CALHM4, MAGEB4, and PRLHR. Each is linked with TRIM66 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM66-to-partner and partner-to-TRIM66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CALHM4 grouped by TRIM66-low versus TRIM66-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM66→partner) and Y-score (partner→TRIM66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CALHM4 →	+0.070	+4.321	<.001	.001	3	2
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	2
BLOOD_Myeloma	PRLHR →	+0.019	+3.906	<.001	.009	3	1
BLOOD_Myeloma	COX6A2 →	+0.782	+3.906	.003	.009	3	1
BLOOD_Myeloma	FDCSP →	+0.121	+4.285	<.001	.003	3	1
BLOOD_Myeloma	KLRC4 →	+0.094	+3.906	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CALHM4 by TRIM66 expression — URINARY_TRACT

Explore this box plot interactively →