TRIM65

Across TCGA patient cohorts, TRIM65 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM65-associated genes across cancer lineages are mTOR, p62 Lck ligand, and SETD2. Each is linked with TRIM65 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM65-to-partner and partner-to-TRIM65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by TRIM65-low versus TRIM65-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM65→partner) and Y-score (partner→TRIM65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	+0.167	+2.321	.039	.035	3	1
UCEC	p62 Lck ligand →	+0.484	+3.179	.003	.010	3	1
UCEC	SETD2 →	-0.218	-2.321	.046	.035	3	1
UCEC	Rab11 →	-0.221	-3.150	.002	.019	2	1
UCEC	Rad50 →	-0.343	-2.321	.004	.035	2	1
UCEC	YB-1 →	-0.187	-2.295	.019	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

mTOR by TRIM65 expression — UCEC

Explore this box plot interactively →