TRIM6

Across TCGA patient cohorts, TRIM6 mutation is significantly associated with the RNA expression of many other genes, with 3,265 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM6-associated genes across cancer lineages are PRR30, CHUK, and ATP6V1D. Each is linked with TRIM6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM6-to-partner and partner-to-TRIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR30 grouped by TRIM6-low versus TRIM6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM6→partner) and Y-score (partner→TRIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRR30 →	+0.031	+4.330	<.001	.002	3	3
SKCM	CHUK →	+0.612	+3.350	.006	.005	3	3
UCEC	ATP6V1D →	+0.439	+2.662	<.001	<.001	3	3
SKCM	PARP2 →	+0.480	+3.331	.008	.005	3	3
SKCM	CHEK1 →	+0.684	+3.218	.002	.009	3	3
UCEC	DLAT →	+0.606	+2.222	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,265 associations by consensus.

PRR30 by TRIM6 expression — LUAD

Explore this box plot interactively →