TRIM6

Across TCGA cell cohorts, TRIM6 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM6-associated genes across cancer lineages are LRRC72, MLN, and PPP1R17. Each is linked with TRIM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM6-to-partner and partner-to-TRIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC72 grouped by TRIM6-low versus TRIM6-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM6→partner) and Y-score (partner→TRIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LRRC72 →	+0.020	+5.000	<.001	.005	3	1
BREAST	MLN →	+0.071	+5.169	<.001	.005	3	1
LARGE_INTESTINE	PPP1R17 →	+0.055	+4.467	.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

LRRC72 by TRIM6 expression — KIDNEY

Explore this box plot interactively →