Across TCGA patient cohorts, TRIM59 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM59-associated genes across cancer lineages are GAPDH, Annexin-1, and 14-3-3_beta. Each is linked with TRIM59 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM59-to-partner and partner-to-TRIM59 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM59→partner) and Y-score (partner→TRIM59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.421	+1.584	.045	.036	3	2
UCEC	Annexin-1 →	+0.898	+3.720	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.098	-3.143	.012	.018	3	1
UCEC	eEF2 →	+0.316	+1.584	.024	.036	3	1
UCEC	ERK2 →	+0.206	+2.000	.006	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.524	+1.884	.008	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

TRIM59 survival (RNA) · tumor vs normal (RNA) · all TRIM59 data types