TRIM54

Across TCGA patient cohorts, TRIM54 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM54-associated genes across cancer lineages are mTOR_pS2448, Shc_pY317, and eEF2. Each is linked with TRIM54 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM54-to-partner and partner-to-TRIM54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TRIM54-low versus TRIM54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM54→partner) and Y-score (partner→TRIM54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.180	-2.986	.016	.035	3	2
UCEC	Shc_pY317 →	-0.178	-2.321	.019	.034	3	2
UCEC	eEF2 →	+0.395	+2.321	.028	.035	3	1
UCEC	EGFR_pY1068 →	-0.309	-2.321	.014	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.219	-2.308	.009	.036	3	1
UCEC	MEK1 →	+0.533	+3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

mTOR_pS2448 by TRIM54 expression — UCEC

Explore this box plot interactively →