TRIM54

Across TCGA cell cohorts, TRIM54 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM54-associated genes across cancer lineages are TMEM196, CDR1, and GSG1L2. Each is linked with TRIM54 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM54-to-partner and partner-to-TRIM54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM196 grouped by TRIM54-low versus TRIM54-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM54→partner) and Y-score (partner→TRIM54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM196 →	+0.045	+4.874	<.001	.002	3	1
BLOOD_Leukemia	CDR1 →	+0.083	+5.060	<.001	.001	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
BLOOD_Leukemia	C5orf67 →	+0.089	+4.409	.007	.005	3	1
BLOOD_Leukemia	OR4A47 →	+0.016	+4.539	<.001	.007	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TMEM196 by TRIM54 expression — BLOOD_Leukemia

Explore this box plot interactively →