TRIM54

Across TCGA cell cohorts, TRIM54 mutation is significantly associated with the mutation status of many other genes, with 3,479 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM54-associated genes across cancer lineages are SGO2, PCDH19, and IRX1. Each is linked with TRIM54 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM54-to-partner and partner-to-TRIM54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGO2 grouped by TRIM54-low versus TRIM54-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM54→partner) and Y-score (partner→TRIM54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SGO2 →	+4.772	+5.339	.004	.004	1	3
LUNG_NSCLC_LUAD	PCDH19 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	IRX1 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	TMPRSS11F →	+5.772	+5.772	.002	.002	1	3
BLOOD_Leukemia	HAPLN3 →	+5.560	+4.736	.003	.003	1	3
LUNG_NSCLC_LUAD	CRX →	+4.772	+5.339	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,479 associations by consensus.

SGO2 by TRIM54 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →