TRIM53BP

Across TCGA pan-cancer cohorts, TRIM53BP Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated TRIM53BP data layer compared with 10 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher TRIM53BP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM53BP expression acts as an unfavorable survival marker.

SARC are the cancer types where TRIM53BP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.175	0.745	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

TRIM53BP–SARC (OS)

Open the SARC breakdown →