TRIM51

Across TCGA patient cohorts, TRIM51 mutation is significantly associated with the RNA expression of many other genes, with 3,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM51-associated genes across cancer lineages are PATL1, FANCE, and NUDC. Each is linked with TRIM51 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRIM51-to-partner and partner-to-TRIM51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PATL1 grouped by TRIM51-low versus TRIM51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM51→partner) and Y-score (partner→TRIM51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PATL1 →	+0.370	+2.010	.005	.005	3	5
LUAD	FANCE →	+0.593	+2.404	<.001	<.001	3	5
SKCM	NUDC →	+0.385	+2.167	<.001	.008	3	4
SKCM	CLSPN →	+0.698	+3.459	.001	.005	3	4
SKCM	SMARCB1 →	+0.380	+2.719	.002	.003	3	4
LUAD	CPSF7 →	+0.338	+2.392	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,668 associations by consensus.

PATL1 by TRIM51 expression — UCEC

Explore this box plot interactively →