TRIM51

Across TCGA patient cohorts, TRIM51 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM51-associated genes across cancer lineages are Shc_pY317, XBP1, and Caspase-7-cleavedD198. Each is linked with TRIM51 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM51-to-partner and partner-to-TRIM51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by TRIM51-low versus TRIM51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM51→partner) and Y-score (partner→TRIM51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.158	-1.652	.001	.006	3	4
LUSC	XBP1 →	+0.177	+2.459	.025	.017	3	3
UCEC	Caspase-7-cleavedD198 →	+0.552	+2.584	.004	.010	3	3
LUSC	HER3 →	-0.256	-1.897	.013	.015	3	2
LUAD	Beclin →	-0.117	-3.157	.039	.018	3	2
COAD	PDK1_pS241 →	-0.146	-2.987	.032	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Shc_pY317 by TRIM51 expression — UCEC

Explore this box plot interactively →