TRIM51

Across TCGA cell cohorts, TRIM51 mutation is significantly associated with the RNA expression of many other genes, with 768 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM51-associated genes across cancer lineages are PNPLA3, FGF23, and TRIM65. Each is linked with TRIM51 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM51-to-partner and partner-to-TRIM51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA3 grouped by TRIM51-low versus TRIM51-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM51→partner) and Y-score (partner→TRIM51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNPLA3 →	+1.514	+3.364	<.001	.002	3	2
LARGE_INTESTINE	FGF23 →	+0.384	+2.807	.001	.003	3	2
LARGE_INTESTINE	TRIM65 →	+0.531	+3.364	.008	.002	3	2
LARGE_INTESTINE	LIMD1 →	+0.702	+3.364	.001	.002	3	2
LARGE_INTESTINE	FBXL14 →	+0.661	+3.364	.006	.002	3	2
LARGE_INTESTINE	CCHCR1 →	+0.669	+3.364	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 768 associations by consensus.

PNPLA3 by TRIM51 expression — LARGE_INTESTINE

Explore this box plot interactively →