TRIM50

Across TCGA pan-cancer cohorts, TRIM50 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM50 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRIM50 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM50 expression acts as an unfavorable survival marker.

LUAD, KIRC, and BLCA are the cancer types where TRIM50 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	IV	0.045	0.717	<.001	36	view →
KIRC	OS	Median	All	0.181	0.805	.002	21	view →
BLCA	DFS	Median	All	0.100	0.626	<.001	18	view →
COAD	OS	Median	All	0.527	0.871	.001	17	view →
SCLC	DFS	Median	All	0.274	0.815	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM50–LUAD (DFS)

Open the LUAD breakdown →