TRIM5

Across TCGA patient cohorts, TRIM5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM5-associated genes across cancer lineages are FASN, PDCD4, and Rab25. Each is linked with TRIM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM5-to-partner and partner-to-TRIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TRIM5-low versus TRIM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM5→partner) and Y-score (partner→TRIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.302	+1.807	.020	.025	3	2
UCEC	PDCD4 →	-0.512	-1.575	<.001	.017	3	2
UCEC	Rab25 →	-0.235	-1.678	.031	.021	3	2
UCEC	EGFR_pY1068 →	-0.214	-1.415	.009	.043	3	1
UCEC	FoxM1 →	+0.204	+2.263	.016	<.001	3	1
UCEC	GSK3-a-b →	-0.118	-1.584	.008	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

FASN by TRIM5 expression — UCEC

Explore this box plot interactively →