TRIM5

Across TCGA cell cohorts, TRIM5 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM5-associated genes across cancer lineages are FAM153B, CRHR1, and BTBD16. Each is linked with TRIM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM5-to-partner and partner-to-TRIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM153B grouped by TRIM5-low versus TRIM5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM5→partner) and Y-score (partner→TRIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM153B →	+0.641	+3.748	<.001	.004	3	1
BLOOD_Leukemia	CRHR1 →	+0.218	+3.995	<.001	.002	3	1
BLOOD_Leukemia	BTBD16 →	+0.069	+3.959	<.001	.005	3	1
BLOOD_Leukemia	NXPH2 →	+0.024	+3.289	.002	.009	3	1
BLOOD_Leukemia	FERD3L →	+0.026	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OR10V1 →	+0.023	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FAM153B by TRIM5 expression — LARGE_INTESTINE

Explore this box plot interactively →