TRIM47

Across TCGA patient cohorts, TRIM47 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM47-associated genes across cancer lineages are GSK-3a-b_pS21_S9, p62 Lck ligand, and Tuberin_pT1462. Each is linked with TRIM47 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM47-to-partner and partner-to-TRIM47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by TRIM47-low versus TRIM47-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM47→partner) and Y-score (partner→TRIM47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.481	+2.179	.024	.034	3	1
UCEC	p62 Lck ligand →	+0.583	+3.459	<.001	.005	3	1
UCEC	Tuberin_pT1462 →	+0.398	+2.331	<.001	.019	3	1
UCEC	CD49b →	-0.359	-2.986	.011	.035	3	1
UCEC	c-Myc →	-0.253	-2.308	.040	.036	3	1
UCEC	Di-Ras3 →	-0.255	-3.156	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GSK-3a-b_pS21_S9 by TRIM47 expression — UCEC

Explore this box plot interactively →