TRIM42

Across TCGA pan-cancer cohorts, TRIM42 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated TRIM42 data layer compared with 15 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TRIM42 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM42 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SCLC show a favorable association.

BRCA, HNSC, and ESCA are the cancer types where TRIM42 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.805	0.963	.012	22	view →
HNSC	OS	Median	IV	0.430	0.735	.010	21	view →
ESCA	OS	Median	All	0.198	0.872	.003	15	view →
LUSC	DFS	Median	All	0.801	0.383	.010	7	view →
PAAD	OS	Median	All	0.282	0.615	.045	6	view →
LGG	OS	Median	All	0.204	0.799	<.001	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
SCLC	OS	Median	III,IV	0.956	0.237	.049	6	view →
LIHC	DFS	Median	All	0.273	0.558	.008	6	view →
LUAD	DFS	Median	IV	0.671	0.893	.019	6	view →
UCEC	DFS	Median	All	0.945	0.828	.032	6	view →
GBM	OS	Median	All	0.075	0.416	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

TRIM42–BRCA (OS)

Open the BRCA breakdown →