TRIM42

Across TCGA cell cohorts, TRIM42 mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM42-associated genes across cancer lineages are ZNF735, GP2, and RTL4. Each is linked with TRIM42 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM42-to-partner and partner-to-TRIM42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF735 grouped by TRIM42-low versus TRIM42-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM42→partner) and Y-score (partner→TRIM42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF735 →	+0.016	+4.643	<.001	.008	3	2
OESOPHAGUS	GP2 →	+0.015	+2.857	.004	.007	3	2
BLOOD_Myeloma	RTL4 →	+0.023	+4.807	<.001	.006	3	2
BREAST	PRAMEF14 →	+0.235	+4.421	<.001	.004	3	2
STOMACH	CABP5 →	+0.013	+4.209	<.001	<.001	3	2
LUNG_NSCLC_LUSC	CRYGD →	+0.040	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

ZNF735 by TRIM42 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →