TRIM41

Across TCGA patient cohorts, TRIM41 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM41-associated genes across cancer lineages are FOXO3a_pS318_S321, p90 RSK, and PCNA. Each is linked with TRIM41 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM41-to-partner and partner-to-TRIM41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TRIM41-low versus TRIM41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM41→partner) and Y-score (partner→TRIM41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.106	-1.990	.018	.009	3	2
UCEC	p90 RSK →	+0.184	+3.169	.007	.018	3	2
UCEC	PCNA →	+0.162	+1.874	.037	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.888	+3.807	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.685	+2.321	<.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.152	-2.087	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FOXO3a_pS318_S321 by TRIM41 expression — UCEC

Explore this box plot interactively →