Across TCGA pan-cancer cohorts, TRIM40 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TRIM40 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher TRIM40 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM40 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

SARC, LUAD, and GBM are the cancer types where TRIM40 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.205	0.826	<.001	6	view →
LUAD	OS	Median	All	0.235	0.697	.034	3	view →
GBM	DFS	Median	All	1.000	0.248	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRIM40 tumor-vs-normal RNA expression · all TRIM40 data types