TRIM4

Across TCGA pan-cancer cohorts, TRIM4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TRIM4 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TRIM4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where TRIM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.312	1.000	.004	37	view →
CCRCC	DFS	Median	III,IV	0.920	0.572	.007	16	view →
HNSC	DFS	Median	All	0.529	0.744	.006	13	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	8	view →
PDAC	OS	Tertile	IV	0.916	0.231	.024	6	view →
LUAD	OS	Quartile	All	0.744	1.000	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TRIM4–LSCC (DFS)

Open the LSCC breakdown →