TRIM4

Across TCGA patient cohorts, TRIM4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM4-associated genes across cancer lineages are CDK1, 14-3-3_beta, and A-Raf_pS299. Each is linked with TRIM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM4-to-partner and partner-to-TRIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by TRIM4-low versus TRIM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM4→partner) and Y-score (partner→TRIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.198	+2.820	.004	.035	3	2
UCEC	14-3-3_beta →	-0.117	-2.571	.012	.011	3	1
UCEC	A-Raf_pS299 →	-0.134	-3.000	.016	.036	3	1
UCEC	FOXO3a →	-0.100	-2.292	.034	.034	3	1
UCEC	JNK2 →	+0.186	+2.817	.044	.036	3	1
UCEC	Ku80 →	+0.270	+1.887	.014	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

CDK1 by TRIM4 expression — UCEC

Explore this box plot interactively →