TRIM38

Across TCGA pan-cancer cohorts, TRIM38 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM38 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRIM38 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TRIM38 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where TRIM38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.876	0.630	.023	8	view →
LSCC	DFS	Quartile	II,III,IV	0.324	0.861	.003	4	view →
PDAC	OS	Median	All	0.460	0.300	.014	4	view →
GBM	DFS	Median	All	0.296	0.442	.037	2	view →
UCEC	DFS	Median	II,III,IV	0.826	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM38–HNSC (OS)

Open the HNSC breakdown →