TRIM38

Across TCGA patient cohorts, TRIM38 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM38-associated genes across cancer lineages are eIF4E, ERK2, and MEK1. Each is linked with TRIM38 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM38-to-partner and partner-to-TRIM38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TRIM38-low versus TRIM38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM38→partner) and Y-score (partner→TRIM38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.207	+2.807	.012	.003	3	1
UCEC	ERK2 →	+0.206	+3.584	.006	.002	3	1
UCEC	MEK1 →	+0.478	+3.169	<.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.366	+3.594	.004	.001	2	2
UCEC	PCNA →	+0.223	+3.169	.008	.018	3	1
UCEC	PDK1_pS241 →	+0.141	+1.598	.035	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by TRIM38 expression — UCEC

Explore this box plot interactively →