TRIM38

Across TCGA cell cohorts, TRIM38 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM38-associated genes across cancer lineages are MSGN1, RNF212B, and SPRR2F. Each is linked with TRIM38 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM38-to-partner and partner-to-TRIM38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by TRIM38-low versus TRIM38-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM38→partner) and Y-score (partner→TRIM38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	RNF212B →	+0.146	+3.678	<.001	.009	3	1
LARGE_INTESTINE	SPRR2F →	+0.629	+3.707	<.001	.009	3	1
BLOOD_Leukemia	DKK4 →	+0.233	+3.623	<.001	.007	3	1
BLOOD_Leukemia	WFDC12 →	+0.163	+3.289	<.001	.009	3	1
BLOOD_Leukemia	DEFB4A →	+0.078	+3.684	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MSGN1 by TRIM38 expression — LARGE_INTESTINE

Explore this box plot interactively →