TRIM37

Across TCGA pan-cancer cohorts, TRIM37 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TRIM37’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRIM37 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM37 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where TRIM37 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM37 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.908	<.001	12	view →
KIRP	All	II,III,IV	+0.864	<.001	11	view →
LIHC	Male	All	+1.077	<.001	9	view →
THCA	Male	III,IV	−0.847	<.001	9	view →
LUAD	Male	III,IV	+1.359	<.001	7	view →
KICH	Female	II,III,IV	−1.175	<.001	7	view →
BRCA	All	III,IV	+0.814	<.001	6	view →
CHOL	Male	All	+2.229	<.001	5	view →
READ	Male	All	+0.740	<.001	5	view →
LUSC	Female	All	+0.686	<.001	5	view →
BLCA	All	All	+0.495	.007	5	view →
STAD	All	II,III,IV	+0.739	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TRIM37–HNSC

Open the HNSC breakdown →