TRIM35

Across TCGA pan-cancer cohorts, TRIM35 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM35 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TRIM35 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM35 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BRCA, READ, and BLCA are the cancer types where TRIM35 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.165	0.924	<.001	36	view →
READ	OS	Median	All	0.281	0.823	.006	6	view →
BLCA	OS	Median	All	0.174	0.720	.007	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	All	0.416	0.198	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM35–BRCA (OS)

Open the BRCA breakdown →