TRIM35

Across TCGA patient cohorts, TRIM35 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM35-associated genes across cancer lineages are Smad1, Smad3, and STAT3_pY705. Each is linked with TRIM35 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM35-to-partner and partner-to-TRIM35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad1 grouped by TRIM35-low versus TRIM35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM35→partner) and Y-score (partner→TRIM35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad1 →	+0.140	+3.169	.035	.019	3	3
UCEC	Smad3 →	+0.154	+2.321	.016	.034	3	2
UCEC	STAT3_pY705 →	-0.413	-2.906	<.001	.001	3	2
UCEC	YB-1_pS102 →	-0.238	-2.222	.002	.011	3	2
UCEC	Caspase-8 →	-0.229	-2.558	.032	.010	3	2
UCEC	Cyclin-B1 →	+0.624	+3.169	.008	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Smad1 by TRIM35 expression — UCEC

Explore this box plot interactively →