TRIM35

Across TCGA cell cohorts, TRIM35 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,161 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TRIM35-associated GO terms across cancer lineages are DNA-templated transcription initiation, tRNA transcription by RNA polymerase III, and Negative regulation of sister chromatid cohesion. Each is linked with TRIM35 in more than 14 cancer types. Because this analysis shows association rather than direction, both TRIM35-to-partner and partner-to-TRIM35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by TRIM35-low versus TRIM35-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM35→partner) and Y-score (partner→TRIM35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated transcription initiation →	+0.068	+1.213	<.001	<.001	3	15
URINARY_TRACT	tRNA transcription by RNA polymerase III →	+0.120	+0.858	<.001	.002	3	12
SKIN	Negative regulation of sister chromatid cohesion →	+0.110	+0.531	<.001	<.001	3	12
BLOOD_Lymphoma	RNA export from nucleus →	+0.109	+0.860	<.001	<.001	3	12
BONE	RNA 3'-end processing →	+0.078	+0.977	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Exit from mitosis →	+0.067	+0.556	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,161 associations by consensus.

DNA-templated transcription initiation by TRIM35 expression — BONE

Explore this box plot interactively →