TRIM35

Across TCGA cell cohorts, TRIM35 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM35-associated genes across cancer lineages are NYAP1, GYPE, and FAM205A. Each is linked with TRIM35 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM35-to-partner and partner-to-TRIM35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NYAP1 grouped by TRIM35-low versus TRIM35-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM35→partner) and Y-score (partner→TRIM35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NYAP1 →	+0.460	+3.125	.004	.008	3	1
LARGE_INTESTINE	GYPE →	+0.011	+2.556	.004	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+3.444	<.001	.001	3	1
LARGE_INTESTINE	GLI2 →	+1.441	+3.234	<.001	.005	3	1
BLOOD_Leukemia	ZAN →	+0.121	+4.133	<.001	.003	3	1
BLOOD_Leukemia	DIP2C-AS1 →	+0.113	+3.896	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

NYAP1 by TRIM35 expression — LARGE_INTESTINE

Explore this box plot interactively →