Across TCGA patient cohorts, TRIM31 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM31-associated genes across cancer lineages are mTOR_pS2448, Bak, and c-Met_pY1235. Each is linked with TRIM31 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM31-to-partner and partner-to-TRIM31 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM31→partner) and Y-score (partner→TRIM31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.208	-3.439	.001	.005	3	2
UCEC	Bak →	+0.364	+3.321	.001	.009	3	2
UCEC	c-Met_pY1235 →	+0.088	+2.000	.008	.032	3	2
UCEC	EGFR_pY1173 →	+0.102	+2.026	.004	.018	2	2
UCEC	eIF4G →	+0.365	+3.321	.009	.010	3	1
UCEC	FoxM1 →	+0.282	+3.807	.015	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

TRIM31 survival (RNA) · tumor vs normal (RNA) · all TRIM31 data types