TRIM3

Across TCGA patient cohorts, TRIM3 mutation is significantly associated with the RNA expression of many other genes, with 3,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM3-associated genes across cancer lineages are MTHFD2, COX15, and SLC7A11. Each is linked with TRIM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM3-to-partner and partner-to-TRIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD2 grouped by TRIM3-low versus TRIM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM3→partner) and Y-score (partner→TRIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTHFD2 →	+0.445	+1.960	.008	.008	3	4
UCEC	COX15 →	+0.437	+1.954	<.001	<.001	3	3
UCEC	SLC7A11 →	+0.772	+2.192	<.001	<.001	3	3
UCEC	BUB3 →	+0.344	+2.660	.001	<.001	3	3
UCEC	RBPJ →	+0.333	+2.617	.001	<.001	3	3
UCEC	ZCCHC4 →	+0.332	+1.546	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,739 associations by consensus.

MTHFD2 by TRIM3 expression — UCEC

Explore this box plot interactively →