TRIM3

Across TCGA patient cohorts, TRIM3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM3-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and ACC1. Each is linked with TRIM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM3-to-partner and partner-to-TRIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRIM3-low versus TRIM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM3→partner) and Y-score (partner→TRIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.796	+2.019	<.001	.001	3	3
UCEC	eIF4E →	+0.210	+1.893	.001	<.001	3	2
UCEC	ACC1 →	+0.290	+1.713	.010	.024	3	2
SKCM	JNK2 →	+0.278	+3.169	.006	.017	3	2
UCEC	MEK1 →	+0.539	+2.485	<.001	<.001	3	2
UCEC	PDCD4 →	-0.560	-2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by TRIM3 expression — UCEC

Explore this box plot interactively →