TRIM3

Across TCGA cell cohorts, TRIM3 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible TRIM3-associated genes across cancer lineages are OR4X2, IFNA1, and OR13C3. Each is linked with TRIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM3-to-partner and partner-to-TRIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by TRIM3-low versus TRIM3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM3→partner) and Y-score (partner→TRIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	2
LUNG_NSCLC_LUSC	IFNA1 →	+0.321	+3.502	.007	.007	3	2
SKIN	OR13C3 →	+0.015	+4.022	<.001	.006	3	2
SKIN	C11orf97 →	+0.028	+3.977	<.001	.001	3	2
SOFT_TISSUE	OR2D3 →	+0.028	+4.930	<.001	.008	3	1
SOFT_TISSUE	TDRD15 →	+0.029	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR4X2 by TRIM3 expression — SOFT_TISSUE

Explore this box plot interactively →