TRIM29

Across TCGA pan-cancer cohorts, TRIM29 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TRIM29 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRIM29 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM29 expression acts as an unfavorable survival marker, although some lineages such as SARC and THCA show a favorable association.

LUAD, SKCM, and KIRC are the cancer types where TRIM29 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.734	0.848	<.001	73	view →
SKCM	OS	Tertile	All	0.680	0.852	<.001	69	view →
KIRC	DFS	Median	All	0.508	0.735	<.001	56	view →
SARC	DFS	Median	All	0.428	0.251	.001	35	view →
PAAD	DFS	Quartile	All	0.172	0.531	<.001	34	view →
LGG	DFS	Tertile	All	0.746	0.884	.003	26	view →
THCA	DFS	Quartile	All	0.921	0.608	.004	26	view →
MESO	DFS	Tertile	II,III,IV	0.247	0.420	.004	24	view →
STAD	DFS	Median	All	0.708	0.605	.023	23	view →
ACC	OS	Tertile	All	0.376	0.798	<.001	20	view →
LIHC	DFS	Quartile	III,IV	0.488	0.154	.002	18	view →
LUSC	DFS	Tertile	II,III,IV	0.673	0.503	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TRIM29–LUAD (OS)

Open the LUAD breakdown →