Across TCGA pan-cancer cohorts, TRIM27 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM27 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRIM27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM27 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where TRIM27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.821	0.983	.001	40	view →
CCRCC	OS	Quartile	All	0.685	0.959	.003	12	view →
LSCC	DFS	Median	II,III,IV	0.872	0.694	.021	8	view →
LUAD	OS	Quartile	II,III,IV	0.824	0.288	.017	5	view →
PDAC	OS	Quartile	III,IV	1.000	0.500	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRIM27 tumor-vs-normal RNA expression · all TRIM27 data types