Across TCGA patient cohorts, TRIM27 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM27-associated genes across cancer lineages are Rab11, Rad50, and Annexin-1. Each is linked with TRIM27 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM27-to-partner and partner-to-TRIM27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM27→partner) and Y-score (partner→TRIM27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab11 →	-0.147	-2.087	.008	.005	3	2
UCEC	Rad50 →	-0.222	-1.678	.017	.023	3	2
UCEC	Annexin-1 →	+0.642	+3.720	.001	<.001	3	2
UCEC	c-Met_pY1235 →	+0.073	+2.584	.009	.001	3	2
UCEC	EGFR_pY1068 →	-0.211	-1.678	.028	.023	3	1
UCEC	FASN →	+0.437	+2.700	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

TRIM27 survival (RNA) · tumor vs normal (RNA) · all TRIM27 data types