Across TCGA cell cohorts, TRIM27 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TRIM27-associated genes across cancer lineages are HTR3D, CBLN4, and ACSM6. Each is linked with TRIM27 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM27-to-partner and partner-to-TRIM27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM27→partner) and Y-score (partner→TRIM27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HTR3D →	+0.020	+6.247	<.001	<.001	3	1
BLOOD_Leukemia	CBLN4 →	+0.006	+5.539	<.001	.003	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
CNS	H2BW1 →	+0.074	+3.700	<.001	.003	3	1
CNS	MUC22 →	+0.031	+3.608	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TRIM27 survival (RNA) · tumor vs normal (RNA) · all TRIM27 data types