TRIM26

Across TCGA patient cohorts, TRIM26 mutation is significantly associated with the RNA expression of many other genes, with 3,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM26-associated genes across cancer lineages are GNPNAT1, USB1, and BCAT2. Each is linked with TRIM26 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM26-to-partner and partner-to-TRIM26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by TRIM26-low versus TRIM26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM26→partner) and Y-score (partner→TRIM26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPNAT1 →	+0.661	+3.119	<.001	<.001	3	2
UCEC	USB1 →	+0.400	+1.923	.001	.009	3	2
UCEC	BCAT2 →	+0.400	+2.091	.004	.001	3	2
UCEC	PSMD11 →	+0.491	+2.960	<.001	<.001	3	2
UCEC	LRRC59 →	+0.427	+1.747	.004	.004	3	2
UCEC	EFTUD2 →	+0.406	+2.091	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,149 associations by consensus.

GNPNAT1 by TRIM26 expression — UCEC

Explore this box plot interactively →