TRIM26

Across TCGA cell cohorts, TRIM26 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TRIM26-associated genes across cancer lineages are C1orf146, ASB17, and OR1L3. Each is linked with TRIM26 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM26-to-partner and partner-to-TRIM26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by TRIM26-low versus TRIM26-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM26→partner) and Y-score (partner→TRIM26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	OR1L3 →	+0.036	+4.029	<.001	.009	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	ARMH2 →	+0.039	+4.228	<.001	.006	3	1
LARGE_INTESTINE	TAFA4 →	+0.142	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

C1orf146 by TRIM26 expression — OVARY

Explore this box plot interactively →