TRIM25

Across TCGA pan-cancer cohorts, TRIM25 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TRIM25 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TRIM25 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM25 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, BLCA, and KICH are the cancer types where TRIM25 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.164	0.712	<.001	24	view →
BLCA	DFS	Median	III,IV	0.090	0.572	<.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SARC	DFS	Median	All	0.038	0.611	<.001	12	view →
UCEC	DFS	Median	II,III,IV	1.000	0.442	.032	8	view →
COAD	DFS	Median	All	0.107	0.784	<.001	6	view →
HNSC	DFS	Median	IV	0.163	0.582	.034	6	view →
LIHC	OS	Median	All	0.015	0.784	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	DFS	Median	All	0.352	0.678	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TRIM25–SCLC (OS)

Open the SCLC breakdown →