TRIM25

Across TCGA pan-cancer cohorts, TRIM25 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM25 data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRIM25 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM25 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

HNSC, COAD, and PDAC are the cancer types where TRIM25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.902	1.000	<.001	19	view →
COAD	DFS	Median	II,III,IV	1.000	0.887	.030	12	view →
PDAC	DFS	Median	II,III,IV	0.349	0.205	.021	8	view →
LUAD	OS	Tertile	III,IV	1.000	0.640	.016	7	view →
CCRCC	DFS	Quartile	All	0.582	0.884	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM25–HNSC (DFS)

Open the HNSC breakdown →