TRIM24

Across TCGA pan-cancer cohorts, TRIM24 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM24 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRIM24 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM24 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where TRIM24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.824	0.947	.035	7	view →
CCRCC	OS	Median	All	0.914	0.770	.016	6	view →
LUAD	OS	Tertile	III,IV	0.885	0.358	.012	5	view →
PDAC	OS	Median	II,III,IV	0.273	0.523	.011	4	view →
LSCC	DFS	Quartile	II,III,IV	0.866	0.481	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM24–HNSC (OS)

Open the HNSC breakdown →