TRIM24

Across TCGA patient cohorts, TRIM24 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM24-associated genes across cancer lineages are PRAS40_pT246, S6_pS240_S244, and ACC_pS79. Each is linked with TRIM24 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM24-to-partner and partner-to-TRIM24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by TRIM24-low versus TRIM24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM24→partner) and Y-score (partner→TRIM24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.137	+1.700	.021	.042	3	3
UCEC	S6_pS240_S244 →	+0.427	+2.321	.002	.005	3	3
UCEC	ACC_pS79 →	+0.241	+2.000	.045	.029	3	2
UCEC	NF2 →	+0.162	+2.459	.031	.019	3	2
UCEC	p27_pT157 →	-0.048	-1.440	.015	.024	3	2
UCEC	PDK1_pS241 →	+0.158	+1.678	.007	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PRAS40_pT246 by TRIM24 expression — UCEC

Explore this box plot interactively →