TRIM24

Across TCGA cell cohorts, TRIM24 mutation is significantly associated with the RNA expression of many other genes, with 450 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM24-associated genes across cancer lineages are COX6A2, CCDC172, and APCS. Each is linked with TRIM24 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM24-to-partner and partner-to-TRIM24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by TRIM24-low versus TRIM24-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM24→partner) and Y-score (partner→TRIM24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COX6A2 →	+0.743	+4.199	<.001	.007	3	2
SKIN	CCDC172 →	+0.004	+4.415	<.001	.007	3	1
CNS	APCS →	+0.185	+5.058	<.001	<.001	3	1
CNS	OR10G7 →	+0.008	+4.772	<.001	.002	3	1
CNS	TFDP3 →	+0.638	+3.874	<.001	.006	3	1
CNS	DUXA →	+0.048	+3.874	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 450 associations by consensus.

COX6A2 by TRIM24 expression — BREAST

Explore this box plot interactively →