TRIM23

Across TCGA pan-cancer cohorts, TRIM23 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TRIM23 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRIM23 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRIM23 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, BLCA, and GBM are the cancer types where TRIM23 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.295	<.001	36	view →
BLCA	OS	Median	IV	0.105	0.605	<.001	24	view →
GBM	OS	Median	All	0.020	0.416	<.001	12	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
LUSC	DFS	Median	II,III,IV	0.145	0.717	.003	6	view →
SKCM	OS	Median	II,III,IV	0.233	0.739	.020	3	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TRIM23–UCEC (DFS)

Open the UCEC breakdown →